Plant growth regulators and Axl and immune checkpoint inhibitors from the edible mushroom Leucopaxillus giganteus.

Mallya IY et al.

2020 Mar 21:1-7.

Abstract

A novel compound, (R) -4-ethoxy-2-hydroxy-4-oxobutanoic acid ( 1 ), and six known compounds ( 2 - 7 ) were isolated from the fruiting bodies of the wild edible mushroom Leucopaxillus giganteus . The planar structure of 1 was determined by the interpretation of spectroscopic data analysis. The absolute configuration of 1 was determined by comparing specific rotation of the synthetic compounds. In the plant regulatory, the isolated compounds ( 1 - assay 7 ) and the chemically prepared compounds ( 8 - 10 ) were evaluated their biological activity against the lettuce ( Lactuca sativa ) growth. Compounds 1 and 3-10 _ showed the significant regulatory activity of lettuce growth. 1 showed the strongest inhibition activity among the all the compounds tested. In the lung cancer, all the compounds were assessed the mRNA expression of Axl and assay immune checkpoints (PD-L1, PD-L2) in the human A549 alveolar epithelial cell line by RT-PCR. Compounds 1 - 10 showed significant inhibition activity against Axl and/or immune checkpoint.

Resource from https://www.ncbi.nlm.nih.gov/pubmed/32200702